THE STATE OF HUMORAL IMMUNITY AT CHRONIC DUST BRONCHITIS AND PNEUMOCONIOSES,
CAUSED BY VARIOUS TYPES FIBROGENIC DUST

Babanov Sergey Anatol'evich, Doctor of medical sciences, professor, head of sub-department of occupational diseases and clinical pharmacology,Samara State Medical University (48 Pionerskaya street, Samara, Russia), s.a.babanov@mail.ru
Budash Dar'ya Sergeevna, Senior laboratory assistant, sub-department of occupational diseases and clinical pharmacology, Samara State Medical University (48 Pionerskaya street, Samara, Russia), s.a.babanov@mail.ru

612.017.1:613.633

10.21685/2072-3032-2016-3-3

Background. The article considers a question of improving the quality of early diagnosing of dust disases of lungs through studying the role of humoral immunity and immune mechanisms in development of the proliferative stage of inflammation and processes of bronchial tubes remodulation at chronic dust bronchitis, silicosis, pneumoconiosis, caused by welding aerosols.
Materials and methods. The authors carried out an immunological examination of 27 people with the first stage of chronic dust bronchitis, 39 people with the se-cond stage of chronic dust bronchitis, 56 people with the first stage of silicosis, 31 people with pneumoconiosis caused by welding aerosols. The obtained data were compared with 60 healthy workers of industrial enterprises and companies having no contact with occupational hazards during their work. The immune status indicators were determined in accordance with recommendations of the WHO and the State research center “The Institute of Immunology” of the Federal biomedical agency. The composition of immunoglobulins А, М, G, E, fibronectin in the blood serum was determined via a solid-state immune-enzyme analysis. The CH50 alexine’s and myeloperoxidase’s hemolytic activity was determined through standard reactions.
Results. The research has resulted in acquisition of data on an increase of the level of all known immunoglobulins in the blood serum in patients with chronic dust bronchitis of the first and second stages. It has been established that it is typical for silicosis and pneumoconiosis to have opposite decreasing levels of IgA and IgM, and increasing indicators of myeloperoxidase, fibronectin, IgG and IgE.
Conclusions. The determination of immunological features of the course of dust diseases of lungs, the revealed features of humoral immunity make it possible to as-certain peculiarities of the origin, course and progress of dust diseases of lungs, which will allow to improve the quality of early diagnostics as well as to optimize strategies of primary and secondary prophylaxis of the given pathology, to predict the course of the disease.

chronic dust bronchitis, silicosis, pneumoconiosis caused by welding aerosols, immunological features, humoral immunity.

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